GPR84 (gpr84_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR84
GENE
GPR84 (EX33)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 84, Inflammation-related G-protein coupled receptor EX33
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
W
|
N
|
S
|
S
|
D
|
A
|
N
|
F
|
S
|
10 |
TM1 | |||||||||
C
|
Y
|
H
|
E
|
S
|
V
|
L
|
G
|
Y
|
R
|
20 |
Y
|
V
|
A
|
V
|
S
|
W
|
G
|
V
|
V
|
V
|
30 |
A
|
V
|
T
|
G
|
T
|
V
|
G
|
N
|
V
|
L
|
40 |
T
|
L
|
L
|
A
|
L
|
A
|
I
|
Q
|
P
|
K
|
50 |
ICL1 | TM2 | ||||||||
L
|
R
|
T
|
R
|
F
|
N
|
L
|
L
|
I
|
A
|
60 |
N
|
L
|
T
|
L
|
A
|
D
|
L
|
L
|
Y
|
C
|
70 |
T
|
L
|
L
|
Q
|
P
|
F
|
S
|
V
|
D
|
T
|
80 |
ECL1 | |||||||||
Y
|
L
|
H
|
L
|
H
|
W
|
R
|
T
|
G
|
A
|
90 |
TM3 | |||||||||
T
|
F
|
C
|
R
|
V
|
F
|
G
|
L
|
L
|
L
|
100 |
F
|
A
|
S
|
N
|
S
|
V
|
S
|
I
|
L
|
T
|
110 |
L
|
C
|
L
|
I
|
A
|
L
|
G
|
R
|
Y
|
L
|
120 |
ICL2 | |||||||||
L
|
I
|
A
|
H
|
P
|
K
|
L
|
F
|
P
|
Q
|
130 |
TM4 | |||||||||
V
|
F
|
S
|
A
|
K
|
G
|
I
|
V
|
L
|
A
|
140 |
L
|
V
|
S
|
T
|
W
|
V
|
V
|
G
|
V
|
A
|
150 |
S
|
F
|
A
|
P
|
L
|
W
|
P
|
I
|
Y
|
I
|
160 |
ECL2 | |||||||||
L
|
V
|
P
|
V
|
V
|
C
|
T
|
C
|
S
|
F
|
170 |
TM5 | |||||||||
D
|
R
|
I
|
R
|
G
|
R
|
P
|
Y
|
T
|
T
|
180 |
I
|
L
|
M
|
G
|
I
|
Y
|
F
|
V
|
L
|
G
|
190 |
L
|
S
|
S
|
V
|
G
|
I
|
F
|
Y
|
C
|
L
|
200 |
I
|
H
|
R
|
Q
|
V
|
K
|
R
|
A
|
A
|
Q
|
210 |
ICL3 | |||||||||
A
|
L
|
D
|
Q
|
Y
|
K
|
L
|
R
|
Q
|
A
|
220 |
S
|
I
|
H
|
S
|
N
|
H
|
V
|
A
|
R
|
T
|
230 |
D
|
E
|
A
|
M
|
P
|
G
|
R
|
F
|
Q
|
E
|
240 |
L
|
D
|
S
|
R
|
L
|
A
|
S
|
G
|
G
|
P
|
250 |
S
|
E
|
G
|
I
|
S
|
S
|
E
|
P
|
V
|
S
|
260 |
A
|
A
|
T
|
T
|
Q
|
T
|
L
|
E
|
G
|
D
|
270 |
S
|
S
|
E
|
V
|
G
|
D
|
Q
|
I
|
N
|
S
|
280 |
K
|
R
|
A
|
K
|
Q
|
M
|
A
|
E
|
K
|
S
|
290 |
P
|
P
|
E
|
A
|
S
|
A
|
K
|
A
|
Q
|
P
|
300 |
TM6 | |||||||||
I
|
K
|
G
|
A
|
R
|
R
|
A
|
P
|
D
|
S
|
310 |
S
|
S
|
E
|
F
|
G
|
K
|
V
|
T
|
R
|
M
|
320 |
C
|
F
|
A
|
V
|
F
|
L
|
C
|
F
|
A
|
L
|
330 |
S
|
Y
|
I
|
P
|
F
|
L
|
L
|
L
|
N
|
I
|
340 |
ECL3 | |||||||||
L
|
D
|
A
|
R
|
V
|
Q
|
A
|
P
|
R
|
V
|
350 |
TM7 | |||||||||
V
|
H
|
M
|
L
|
A
|
A
|
N
|
L
|
T
|
W
|
360 |
L
|
N
|
G
|
C
|
I
|
N
|
P
|
V
|
L
|
Y
|
370 |
H8 | |||||||||
A
|
A
|
M
|
N
|
R
|
Q
|
F
|
R
|
Q
|
A
|
380 |
Y
|
G
|
S
|
I
|
L
|
K
|
R
|
G
|
P
|
R
|
390 |
C-term | |||||
S
|
F
|
H
|
R
|
L
|
H
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page